This one is for science lovers!
The diagram depicts how heightened signaling in neurons leads to a state of positive charge (depolarization). Activated (presynaptic) neurons start releasing chemicals called neurotransmitters, like excitatory glutamate. When the responding (postsynaptic) neurons are activated sufficiently, they initiate production of endocannabinoids – 2-AG and AEA. These endocannabinoid molecules bind to cannabinoid receptors 1 and 2 (CB1 and CB2). CB1 receptors regulate brain cell signaling and CB2 – inflammation in the brain.
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Ten steps – test your knowledge.
(1) Electrical potentials – action potentials lead to
(2) Depolarization (positive charge) in a presynaptic neuron
(3) Influx of calcium via voltage-gated calcium channels
(4) Neurotransmitter (glutamate) exocytosis
(5) Glutamate binding to postsynaptic receptor channels
(6) Depolarization of postsynaptic neuron
(7) Calcium influx via voltage-gated calcium channels
(8) Synthesis of endocannabinoids on demand
(9) CB1 and CB2 receptor binding by the endocannabinoids
(10) Reduction of calcium influx and exocytosis
Source/ Author Dr. Jokūbas Žiburkus